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Issue cover for Volume 25, Issue 6

May 2023

Volume 25Issue 6SupplementS7-S300

Abstracts of the 29th Annual ISCT Meeting May 31-June 3, 2023

Issue cover for Volume 25, Issue 6

Current Issue
Articles in Press
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Please select at least one article in order to proceed.

Editorial Board

Editorial Board

Published in issue: May 2023

i

PDF

Miscellaneous

Table of Contents

Published in issue: May 2023

ii

PDF

Introduction from the President

Published in issue: May 2023

iii

PDF

Welcome to ISCT 2023

Published in issue: May 2023

iv-v

PDF

Abstract only

Process Development and Manufacturing: EARLY DETECTION AND METABOLIC PATHWAY IDENTIFICATION OF T-CELL ACTIVATION BY IN-PROCESS INTRACELLULAR MASS

A.L. Culberson,
A.C. Bowles-Welch,
B. Wang,
...
A. Jimenez,
K. Roy,
A. Fedorov

Published in issue: May 2023

S7-S8

PDF

Process Development and Manufacturing: IMMUNOSTIMULATORY PHOTOTHERMAL PRUSSIAN BLUE NANOPARTICLES ENGINEER TUMOR-SPECIFIC T CELLS FOR ADOPTIVE THERAPY

E.E. Sweeney,
P. Sekhri,
N. Muniraj,
...
C. Sanchez,
C. Cruz,
R. Fernandes

Published in issue: May 2023

S8

PDF

Process Development and Manufacturing: FULLY AUTOMATED CAR-T CELL MANUFACTURING SYSTEM ENABLES PROCESS INSIGHT AND CONTROL

L. Herbst,
F. Erkens,
S. Hort,
...
S. Goldrick,
I. Papantoniou,
R. Schmitt

Published in issue: May 2023

S8-S9

PDF

Process Development and Manufacturing: MULTIPLE EFFICIENCIES GAINED BY IMPLEMENTING A SIGNIFICANTLY SHORTER MANUFACTURING SCHEDULE FOR PRODUCTION OF CAR T CELL PRODUCTS

G. Plesa,
A.L. Brennan,
J. Rojas Levine,
...
A. Fesnak,
M.M. Davis,
D. Siegel

Published in issue: May 2023

S9

PDF

Process Development and Manufacturing: CAR-T CELLS MANUFACTURED VIA POSITIVE AND NEGATIVE IMMUNOMAGNETIC T CELL SELECTION SHOW DIFFERENT TUMOR KILLING RATES, CYTOKINE PROFILES, AND γδ T CELL OUTPUT

H.W. Song,
M. Benzaoui,
S. Underwood,
...
C. Chien,
N. Taylor,
S.L. Highfill

Published in issue: May 2023

S9

PDF

Process Development and Manufacturing: DESIGNING, BUILDING AND COMMISSIONING A MULTI-PRODUCT CELL AND GENE THERAPY CLEANROOM FACILITY: LESSONS LEARNED

M. van Pel,
T. Pritchard-Meaker

Published in issue: May 2023

S9-S10

PDF

iPSC: A PHASE I/IIA TRIAL TO TEST SAFETY AND FEASIBILITY OF AN AUTOLOGOUS IPS CELL-DERIVED RETINAL PIGMENT EPITHELIUM PATCH IN AGE-RELATED MACULAR DEGENERATION PATIENTS

K. Bharti

Published in issue: May 2023

S10

PDF

iPSC: SCALABLE PLATFORM FOR HUMAN IPSCS PRODUCTION IN AN AUTOMATED STIRRED TANK BIOREACTOR SYSTEM FOR BIOPRINTING APPLICATIONS

R. Ladi,
D. Ho,
S. Lee,
...
Q. Vicard,
K. Katikireddy,
M. Skylar-Scott

Published in issue: May 2023

S10

PDF

iPSC: DEVELOPMENT OF AUTOMATED CELL AND COLONY MANAGEMENT PROTOCOLS FOR GENERATION OF HUMAN INDUCED PLURIPOTENT STEM CELLS

V. Luangphakdy,
M. Swamydas,
B. Handerhan,
K. Powell,
G.F. Muschler

Published in issue: May 2023

S11-S12

PDF

iPSC: A PHASE I CLINICAL TRIAL OF IPSC-DERIVED MSCS (CYP-001) IN STEROID-RESISTANT ACUTE GVHD: TWO YEAR FOLLOW-UP RESULTS

K. Kelly,
A. Bloor,
A. Patel,
...
D.T. Yeung,
I. Slukvin,
J. Rasko

Published in issue: May 2023

S12

PDF

iPSC: GMP MANUFACTURING AND RELEASE ASSAYS FOR INDUCED PLURIPOTENT STEM CELLS DERIVED RETINAL PIGMENT EPITHELIUM “PATCH” FOR AUTOLOGOUS CELL-BASED THERAPY FOR AGE-RELATED MACULAR DEGENERATION

R. Sharma,
R. Dejene,
S. Jha,
K. Bharti

Published in issue: May 2023

S12-S13

PDF

iPSC: ENGINEERING THE MULTICELLULAR NICHE FOR T CELL DIFFERENTIATION

M.E. Smerchansky,
J. Rolland,
K. Saha,
M. Kinney

Published in issue: May 2023

S13

PDF

Tissue Engineering: GENERATION OF UNIVERSAL CELLULAR GRAFTS UTILIZING SIGNALING-DEFICIENT MEMBRANE-BOUND CD45 ENGAGERS

A. Hussain,
D.K. Mohammad,
M. Karvouni,
...
A.K. Wagner,
H. Ljunggren,
E. Alici

Published in issue: May 2023

S13-S14

PDF

Regulatory Affairs, Quality Systems, Policy, and Ethics: FDA CYTOTOXICITY AND POTENCY REVIEW: OPPORTUNITIES FOR ASSAY CLARITY

J.S. Barber-Rotenberg,
R.M. Leskowitz,
J. Jadlowsky,
...
B.L. Levine,
A. Chew,
C. June

Published in issue: May 2023

S14

PDF

Hematopoietic Stem/Progenitor Cells and Engineering: LONG-TERM DATA ON IMMUNE MONITORING OF CHILDREN GIVEN TCRαβ/CD19 CELL DEPLETED HLA-HAPLOIDENTICAL STEM TRANSPLANTATION (HAPLO-HSCT)

V. Bertaina,
R. Sborgia,
O. Marini,
...
P. Merli,
F. Galaverna,
F. Locatelli

Published in issue: May 2023

S14-S15

PDF

Embryonic, Organ and Other Tissue Specific Stem Cells: DISCOVERY AND CHARACTERIZATION OF A NOVEL RESIDENT ENDOTHELIAL STEM-LIKE CELL THAT MEDIATES RAPID LUNG MICROVASCULAR REGENERATION IN AN ENDOTHELIAL CELL ABLATION MODEL OF ACUTE LUNG INJURY

N.D. Cober,
R.S. Godoy,
L. Wang,
K. Schlosser,
D.J. Stewart

Published in issue: May 2023

S15

PDF

Regulatory Affairs, Quality Systems, Policy, and Ethics: EVALUATION OF PERCENTAGE CHANGE IN PRE-DONATION AND POST-DONATION LABORATORY VALUES AFTER REPEATED (MNC), APHERESIS DONATIONS

C. Mooney,
S. Blakenbaker,
T. Ipe,
J.L. Chain

Published in issue: May 2023

S15-S16

PDF

Hematopoietic Stem/Progenitor Cells and Engineering: TREATMENT OF ACUTE ICHEMIC STROKE WITH BONE MARROW MONONUCLEAR CELLS. A PHASE IIB RANDOMIZED, DOSE-FINDING, SINGLE-BLIND CONTROLLED MULTICENTER TRIAL

F. Moniche,
B. Quijano-Ruiz,
R. Valverde,
...
O. Fernandez,
G. Carmona,
R. Mata

Published in issue: May 2023

S16

PDF

iPSC: ENGINEERING 3D MICRO-COMPARTMENTS FOR HIGHLY EFFICIENT AND SCALE-INDEPENDENT EXPANSION OF HUMAN PLURIPOTENT STEM CELLS IN BIOREACTORS

M. Feyeux,
K. Alessandri

Published in issue: May 2023

S16-S17

PDF

Mesenchymal Stem/Stromal Cells: MESENCHYMAL STROMAL CELL THERAPEUTIC EFFICACY AND MACROPHAGE MEMORY ARE ENHANCED BY HUMAN MIF IN ALLERGIC AIRWAY INFLAMMATION

K. English,
H. Dunbar,
I. Hawthorne,
M. Armstrong,
S. Donelly

Published in issue: May 2023

S17

PDF

Mesenchymal Stem/Stromal Cells: MITOCHONDRIAL TRANSFER FUNCTIONALLY RESTORES THE HUMAN OSTEOARTHRITIS (OA) CHONDROCYTE, IS PROTECTIVE AGAINST OXIDATIVE STRESS AND IMPROVES OA IN AN ANIMAL MODEL OF DISEASE

F.E. Figueroa,
M. Khoury,
A. Court,
...
A. Ortoloff,
C. Pradenas,
P. Luz-Crawford

Published in issue: May 2023

S17-S18

PDF

Mesenchymal Stem/Stromal Cells: A NOVEL AND SIMPLE METHOD FOR OVERCOMING POST-THAW DYSFUNCTION OF CRYOPRESERVED MSC BY CELL-CYCLE SYNCHRONIZATION PRIOR TO FREEZING

B.H. Johnstone,
D. Gu,
C. Lin,
J. Du,
E.J. Woods

Published in issue: May 2023

S18

PDF

Process Development and Manufacturing: “LIVE” CELL SHIPMENT: A FORWARD-LOOKING TRANSPORT OPTION FOR “CRYO-SENSITIVE” CELL-BASED THERAPIES

L. Roßbach,
P. Franz,
A. Dünkel,
S. Fricke,
K. Adlkofer,
G. Deblandre

Published in issue: May 2023

S19

PDF

Tissue Engineering: TRACEABILITY BEYOND BORDERS: DEVELOPMENT OF A GLOBAL STANDARD FOR THE LABELING OF TISSUE-ENGINEERED PRODUCTS

M. Freire,
K. Moniz,
J. Allickson,
...
E. McGrath,
M. Hildebrandt,
I. Slaper-Cortenbach

Published in issue: May 2023

S19

PDF

Exosomes/EVs: MESENCHYMAL STROMAL CELL EXTRACELLULAR VESICLES VARIATION FOR IMMUNOMODULATION AND TISSUE REPAIR

E.J. Carson,
T. Bonfield,
V. Krishna,
R. Midura,
G.F. Muschler

Published in issue: May 2023

S19-S20

PDF

Exosomes/EVs: IMMUNOLOGICAL EFFECTS OF EXTRACELLULAR VESICLES FROM BONE MARROW-DERIVED MESENCHYMAL STEM CELLS ON GLIADIN-SPECIFIC T-CELLS

R. Ciccocioppo,
V. Zuliani,
A. Adamo,
...
I. Mottola,
G. Dal Pozzo,
C. Gianfrani

Published in issue: May 2023

S20

PDF

Exosomes/EVs: LARGE-SCALE MANUFACTURING AND CHARACTERISATION OF EXTRACELLULAR VESICLES DERIVED FROM UMBILICAL CORD MESENCHYMAL STROMAL CELLS (MSC-EVS) IN A GMP COMPLIANT SYSTEM

A. Rajendran,
Z. Lee,
M. Ganeson-Koo,
...
K. Then,
G. Ooi,
S. Cheong

Published in issue: May 2023

S20-S21

PDF

Exosomes/EVs: COMPARISON OF CYTOPROTECTIVE AND PRO-ANGIOGENIC PROPERTIES BETWEEN WHOLE SECRETOME AND EXOSOMES DERIVED FROM HUMAN AMNIOTIC MESENCHYMAL STEM CELLS (HAMSCS)

C. Guarona,
D. Di Martino,
E. Saraceno,
...
S. Cerri,
M. Mura,
M. Gnecchi

Published in issue: May 2023

S21-S22

PDF

Exosomes/EVs: SUCCESSFUL DEVELOPMENT OF A SCALABLE AND ROBUST PROCESS FOR MSC-EV PRODUCTION

S. Lenzini,
J. Jung,
G. Patel,
...
M. Boychyn,
E. Zakhem,
J.A. Rowley

Published in issue: May 2023

S22

PDF

Exosomes/EVs: MSC EXOSOMES ENHANCE M2 MACROPHAGE POLARIZATION THROUGH CD73/NT5E ACTIVITY

W. Toh,
K. Teo,
R. Lai,
J. Hui,
S. Lim

Published in issue: May 2023

S22

PDF

Gene Editing/Gene Therapies: HOMOLOGY-INDEPENDENT TARGETED INSERTION (HITI) ENABLES GUIDED CAR KNOCK-IN AND EFFICIENT CLINICAL SCALE CAR-T CELL MANUFACTURING

H. Balke-Want,
V. Keerthi,
N. Gkitsas,
...
E. Sotillo,
C. Mackall,
S. Feldman

Published in issue: May 2023

S22-S24

PDF

Gene Editing/Gene Therapies: NO MORE SHOTS IN THE DARK: MODELING CAR T CELL TRAFFICKING

E. Bugallo Blanco,
R. Kasahni,
J. Cleaver,
J. Foster,
J. Sosabowski,
S. Papa

Published in issue: May 2023

S24-S25

PDF

Gene Editing/Gene Therapies: UCART20X22: ALLOGENEIC DUAL CAR T-CELLS FOR THE TREATMENT OF B-CELL MALIGNANCIES

B. Aranda Orgilles,
I. Chion-Sotinel,
J. Skinner,
...
P. Duchateau,
R. Galetto,
L. Poirot

Published in issue: May 2023

S25

PDF

Gene Editing/Gene Therapies: ENHANCED MITOCHONDRIAL BASE EDITING SYSTEM FOR NEAR COMPLETE MITOCHONDRIAL GENOME EDITING IN HUMAN PRIMARY CELLS SUITABLE FOR DISEASE MODELING AND FOR POTENTIAL THERAPEUTIC APPLICATIONS

B. Kar,
L. Rai Thulung,
S.R. Castillo,
A. Sabharwal,
K. Clark,
S. Ekker

Published in issue: May 2023

S25

PDF

Gene Editing/Gene Therapies: GENERATION OF GENETICALLY ENGINEERED MEGAKARYOCYTES TO PREVENT ALLOGENEIC IMMUNE RESPONSES AFTER TRANSFUSION

A. Rovai,
R. Dettmer,
R. Blasczyk,
C. Figueiredo

Published in issue: May 2023

S26

PDF

Gene Editing/Gene Therapies: GDA-201: PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF CRYOPRESERVED NICOTINAMIDE-EXPANDED ALLOGENEIC NATURAL KILLER CELLS DEMONSTRATE AN ACTIVATED AND NON-EXHAUSTED PHENOTYPE

I. Solomon,
O. Berhani-Zipori,
M. Gamliel,
...
Y. Yoffe-Mizrahi,
R. Simantov,
Y. Geffen

Published in issue: May 2023

S26

PDF

Mesenchymal Stem/Stromal Cells: TRANSPLANTATION OF MITOCHONDRIA ISOLATED FROM MSCS ALLEVIATES ENDOTHELIAL DYSFUNCTION IN THE PRE-CLINICAL MODEL OF ARDS

D.D. Caldeira,
J.D. Silva,
P.R. Rocco,
P.L. Silva,
F.F. Cruz,
A. Krasnodembskaya

Published in issue: May 2023

S26-S27

PDF

Mesenchymal Stem/Stromal Cells: A1-REPROGRAMMED MSCS AS A POTENT ANTI-CANCER VACCINE AGAINST SOLID TUMOURS

M.P. Gonçalves,
J. Bikorimana,
S. Plouffe,
M. Rafei

Published in issue: May 2023

S27-S28

PDF

Mesenchymal Stem/Stromal Cells: SPATIAL TRANSCRIPTOMICS IDENTIFIES PRO-ANGIOGENIC PERIVASCULAR STEM CELLS IN ADIPOSE TISSUE

O. Inoue,
C. Goten,
D. Hashimuko,
...
J. Sanchez-Gurmaches,
S. Usui,
M. Takamura

Published in issue: May 2023

S28-S29

PDF

Mesenchymal Stem/Stromal Cells: PATIENT RESPONSES TO MESENCHYMAL STROMAL CELL (MSC) THERAPY IN OSTEOARTHRITIS ARE ASSOCIATED WITH DIFFERENTIAL CLINICAL PHENOTYPES, MOLECULAR ENDOTYPES, AND MSC CRITICAL QUALITY ATTRIBUTES

K.P. Robb,
R. Rabani,
J. Chahal,
A. Perruccio,
R. Gandhi,
S. Viswanathan

Published in issue: May 2023

S29

PDF

Mesenchymal Stem/Stromal Cells: LOCAL MANUFACTURING PROCESSES CONTRIBUTE TO VARIABILITY IN HUMAN MESENCHYMAL STROMAL CELL (MSC) EXPANSION WHILE GROWTH MEDIA SUPPLEMENTS CONTRIBUTE TO VARIABILITY IN GENE EXPRESSION AND CELL FUNCTION. THE BEST COLLABORATIVE STUDY

B. Shaz,
R. Schäfer,
M. Fontaine,
...
D.C. Marks,
H. Geng,
S. Pati

Published in issue: May 2023

S29-S30

PDF

Mesenchymal Stem/Stromal Cells: PRELIMINARY RESULTS FOR THE CELLULAR IMMUNO-THERAPY FOR COVID-19-RELATED ARDS MULTICENTRE CANADIAN RANDOMIZED CLINICAL TRIAL: CIRCA-19 PHASE 2 RCT

D.J. Stewart,
S. English,
D. Fergusson,
...
D.W. Courtman,
S. Khan,
S. Hodgins

Published in issue: May 2023

S30

PDF

Immunotherapy: EVALUATION OF MEMORY T CELLS AS ADOPTIVE THERAPY IN CORONAVIRUS PNEUMONIA AND/OR LYMPHOPENIA: A PHASE II CLINICAL TRIAL (RELEASE NCT04578210)

C. Ferreras,
C. Hernández,
A. Martín-Quirós,
...
B. Soria,
C. Solano,
A. Perez-Martinez

Published in issue: May 2023

S30-S31

PDF

Immunotherapy: EFFICIENT MULTIPLEX CELL ENGINEERING OF HYPOIMMUNOGENIC AND ALLOGENEIC CAR T-CELLS USING MICAR TECHNOLOGY

A. Šakić,
B. Ponsard,
M. Mansuy,
...
S. Ilmjärv,
A. Roussel-Gervais,
M. Alessandrini

Published in issue: May 2023

S31-S32

PDF

Immunotherapy: IN VIVO TRACKING OF ADENOVIRAL-TRANSDUCED SPIO-LABELED BONE MARROW-DERIVED DENDRITIC CELLS USING MPI

C. Fink,
J.J. Gevaert,
J.D. Dikeakos,
P. Foster,
G. Dekaban

Published in issue: May 2023

S32-S33

PDF

Immunotherapy: MULTI-TUMOR ASSOCIATED ANTIGEN SPECIFIC T CELL (TAA-T) THERAPY TO TREAT PEDIATRIC PATIENTS WITH HIGH-RISK CNS TUMORS: THE REMIND TRIAL

A. Geiger,
R. Diccocio,
M. Fortiz,
...
C. Cruz,
E. Hwang,
C. Bollard

Published in issue: May 2023

S33

PDF

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