Author Response to Bonig and Lehmann

      We thank Drs Lehmann and Bonig for their comments on our apheresis algorithm. We are encouraged to hear of the early external validation of our web application, including in pediatric populations.
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        • Bonig H
        • Chabannon C
        • Lozano M
        Providing the Starting Material to the Manufacturer of an Approved and Commercially Available Autologous CAR-T Cell Treatment.
        in: Kröger N Gribben J Chabannon C Yakoub-Agha I Einsele H EBMT/EHACAR-T cell handbook : Chapter 6. Springer, Cham2022: 31-35

      Linked Article

      • Predicting chimeric antigen receptor apheresis process volume
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          The recent work by O'Reilly et al. [1] provides an elegant tool for chimeric antigen receptor (CAR)–T-cell apheresis planning by generating a formula that predicts the process volume required to achieve a certain target dose of T cells. The formula is mathematically much more sophisticated than the referenced one that we had previously proposed. Our “formula” is solely the estimate that at least 40% of T cells presented at the connector will be collected into the product bag [2]. O'Reilly et al.
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