Abstract
The International Society for Cell & Gene Therapy Scientific Signature Series event
“Therapeutic Advances With Native and Engineered Human EVs” took place as part of
the International Society for Cell & Gene Therapy 2022 Annual Meeting, held from May
4 to 7, 2022, in San Francisco, California, USA. This was the first signature series
event on extracellular vesicles (EVs) and a timely reflection of the growing interest
in EVs, including both native and engineered human EVs, for therapeutic applications.
The event successfully gathered academic and industrial key opinion leaders to discuss
the current state of the art in developing and understanding native and engineered
EVs and applying our knowledge toward advancing EV therapeutics. Latest advancements
in understanding the mechanisms by which native and engineered EVs exert their therapeutic
effects against different diseases in animal models were presented, with some diseases
such as psoriasis and osteoarthritis already reaching clinical testing of EVs. The
discussion also covered various aspects relevant to advancing the clinical translation
of EV therapies, including EV preparation, manufacturing, consistency, site(s) of
action, route(s) of administration, and luminal cargo delivery of RNA and other compounds.
Key Words
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Article info
Publication history
Published online: March 15, 2023
Accepted:
February 15,
2023
Received:
November 1,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.
