Abstract
Backgound Aims: This meta-analysis aims at summarizing the whole body of research
on cell therapies for acute myocardial infarction (MI) in the mouse model to bring
forward ongoing research in this field of regenerative medicine. Despite rather modest
effects in clinical trials, pre-clinical studies continue to report beneficial effects
of cardiac cell therapies for cardiac repair following acute ischemic injury. Results:
The authors’ meta-analysis of data from 166 mouse studies comprising 257 experimental
groups demonstrated a significant improvement in left ventricular ejection fraction
of 10.21% after cell therapy compared with control animals. Subgroup analysis indicated
that second-generation cell therapies such as cardiac progenitor cells and pluripotent
stem cell derivatives had the highest therapeutic potential for minimizing myocardial
damage post-MI. Conclusions: Whereas the vision of functional tissue replacement has
been replaced by the concept of regional scar modulation in most of the investigated
studies, rather basic methods for assessing cardiac function were most frequently
used. Hence, future studies will highly benefit from integrating methods for assessment
of regional wall properties to evolve a deeper understanding of how to modulate cardiac
healing after acute MI.
Graphical abstract
Graphical Abstract
Key Words
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Article info
Publication history
Published online: March 06, 2023
Accepted:
January 24,
2023
Received:
October 18,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.
