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Therapeutic modulation of V Set and Ig domain-containing 4 (VSIG4) signaling in immune and inflammatory diseases

  • Author Footnotes
    ⁎ These authors contributed equally to this work.
    You Li
    Footnotes
    ⁎ These authors contributed equally to this work.
    Affiliations
    Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China

    Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China
    Search for articles by this author
  • Author Footnotes
    ⁎ These authors contributed equally to this work.
    Qi Wang
    Footnotes
    ⁎ These authors contributed equally to this work.
    Affiliations
    Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China

    Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China
    Search for articles by this author
  • Jiaxin Li
    Affiliations
    Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China

    Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China
    Search for articles by this author
  • Aohan Li
    Affiliations
    Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China

    Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China
    Search for articles by this author
  • Qianqian Wang
    Affiliations
    Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China

    Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China
    Search for articles by this author
  • Qinggao Zhang
    Correspondence
    Correspondence: Qinggao Zhang and Yingqing Chen, Chronic Disease Research Center, Medical College, Dalian University, Dalian, 116622 Liaoning, China.
    Affiliations
    Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China

    Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China
    Search for articles by this author
  • Yingqing Chen
    Correspondence
    Correspondence: Qinggao Zhang and Yingqing Chen, Chronic Disease Research Center, Medical College, Dalian University, Dalian, 116622 Liaoning, China.
    Affiliations
    Chronic Disease Research Center, Medical College, Dalian University, Dalian, Liaoning, China

    Engineering Technology Research Center for the Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian, Liaoning, China
    Search for articles by this author
  • Author Footnotes
    ⁎ These authors contributed equally to this work.
Published:January 13, 2023DOI:https://doi.org/10.1016/j.jcyt.2022.12.004

      Abstract

      Inflammation is the result of acute and chronic stresses, caused by emotional or physical trauma, or nutritional or environmental pollutants, and brings serious harm to human life and health. As an important cellular component of the innate immune barrier, the macrophage plays a key role in maintaining tissue homeostasis and promoting tissue repair by controlling infection and resolving inflammation. Several studies suggest that V Set and Ig domain-containing 4 is specifically expressed in tissue macrophages and is associated with a variety of inflammatory diseases. In this paper, we mainly summarize the recent research on V Set and Ig domain-containing 4 structures, functions, function and roles in acute and chronic inflammatory diseases, and provide a novel therapeutic avenue for the treatment of inflammatory diseases, including nervous system, urinary, respiratory and metabolic diseases.

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