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Scientific venturing for early-stage professionals (ESPs), a key concept in the innovation ecosystem

  • Author Footnotes
    ⁎ Co-authors shown in alphabetical order.
    Andrés Caicedo
    Correspondence
    Correspondence: Andrés Caicedo, Universidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Escuela de Medicina, Quito, Ecuador.
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    ⁎ Co-authors shown in alphabetical order.
    Affiliations
    Universidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Escuela de Medicina, Quito, Ecuador

    Universidad San Francisco de Quito USFQ, Instituto de Investigaciones en Biomedicina iBioMed, Quito, Ecuador

    Mito-Act Research Consortium, Quito, Ecuador

    Sistemas Médicos SIME, Universidad San Francisco de Quito USFQ, Quito, Ecuador
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    Paola Robayo
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    ⁎ Co-authors shown in alphabetical order.
    Affiliations
    Universidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Escuela de Medicina, Quito, Ecuador

    Universidad San Francisco de Quito USFQ, Instituto de Investigaciones en Biomedicina iBioMed, Quito, Ecuador

    Mito-Act Research Consortium, Quito, Ecuador
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    ⁎⁎ Co-authors, equal contribution and shown in alphabetical order.
    Emilia Morales
    Footnotes
    ⁎⁎ Co-authors, equal contribution and shown in alphabetical order.
    Affiliations
    Universidad San Francisco de Quito USFQ, Instituto de Investigaciones en Biomedicina iBioMed, Quito, Ecuador

    Mito-Act Research Consortium, Quito, Ecuador

    Biología, Colegio de Ciencias Biológicas y Ambientales COCIBA, Universidad San Francisco de Quito USFQ, Quito, Ecuador
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  • Author Footnotes
    ⁎⁎ Co-authors, equal contribution and shown in alphabetical order.
    Aldana Moyano
    Footnotes
    ⁎⁎ Co-authors, equal contribution and shown in alphabetical order.
    Affiliations
    Universidad San Francisco de Quito USFQ, Instituto de Investigaciones en Biomedicina iBioMed, Quito, Ecuador

    Mito-Act Research Consortium, Quito, Ecuador

    Instituto de investigaciones biotecnológicas IIB, Universidad Nacional de San Martín, Buenos Aires, Argentina
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    Diego Barba
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    ⁎⁎⁎ Co-authors shown in alphabetical order.
    Affiliations
    Universidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Escuela de Medicina, Quito, Ecuador

    Universidad San Francisco de Quito USFQ, Instituto de Investigaciones en Biomedicina iBioMed, Quito, Ecuador

    Mito-Act Research Consortium, Quito, Ecuador
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    Kevin Zambrano
    Footnotes
    ⁎⁎⁎ Co-authors shown in alphabetical order.
    Affiliations
    Universidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Escuela de Medicina, Quito, Ecuador

    Universidad San Francisco de Quito USFQ, Instituto de Investigaciones en Biomedicina iBioMed, Quito, Ecuador

    Mito-Act Research Consortium, Quito, Ecuador

    School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands

    Instituto de Neurociencias, Universidad San Francisco de Quito USFQ, Quito, Ecuador
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  • Karina Castillo
    Affiliations
    Universidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Escuela de Medicina, Quito, Ecuador

    Universidad San Francisco de Quito USFQ, Instituto de Investigaciones en Biomedicina iBioMed, Quito, Ecuador

    Mito-Act Research Consortium, Quito, Ecuador
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  • Tatiana Maron-Gutierrez
    Affiliations
    Mito-Act Research Consortium, Quito, Ecuador

    Fundação Oswaldo Cruz, FIOCRUZ Instituto Oswaldo Cruz (IOC), Rio de Janeiro, Brazil
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  • Author Footnotes
    ⁎ Co-authors shown in alphabetical order.
    ⁎⁎ Co-authors, equal contribution and shown in alphabetical order.
    ⁎⁎⁎ Co-authors shown in alphabetical order.
Published:December 19, 2022DOI:https://doi.org/10.1016/j.jcyt.2022.11.012

      Abstract

      Early-stage professionals (ESPs) and senior scientists who want to transition from academia to the industry need support to develop new skills and know-how to endeavor this challenge. However, this topic is significantly underserved in the field of cell and gene therapy, slowing down ESPs' potential to make this step. The authors of this article, members of the ESPs in the South and Central America Subcommittee at the International Society for Cell and Gene Therapy, propose the concept of “scientific venturing,” which stands for the process by which scientists become entrepreneurs or part of a company. In our article, we provide key aspects to understand this concept, considering key personality traits that need to be developed and a discussion about the “innovation ecosystem.” Later, we consider how scientific venturing may result in an increase in difficulty in nascent innovation ecosystems such as Latin America, in comparison with those more advanced and mature in high-income countries. Finally, we provide key information for the ESPs and other professionals about the stages of private and public investment, including information about the resources needed for the sustainability of companies and startups. Understanding what scientific venturing involves for ESPs is key to taking advantage of the maturity of an innovation ecosystem, its network, and available opportunities.

      Key Words

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      References

        • Beck S
        • Bergenholtz C
        • Bogers M
        • Brasseur T-M
        • Conradsen ML
        • Di Marco D
        • et al.
        The Open Innovation in Science research field: a collaborative conceptualisation approach.
        Industry and Innovation. 2020; : 1-50https://doi.org/10.1080/13662716.2020.1792274
        • Sachs JD
        • Schmidt-Traub G
        • Mazzucato M
        • Messner D
        • Nakicenovic N
        • Rockström J.
        Six transformations to achieve the sustainable development goals.
        Nat Sustain. 2019; https://doi.org/10.1038/s41893-019-0352-9
        • Stewart MD
        • Keane A
        • Butterfield LH
        • Levine BL
        • Thompson B
        • Xu Y
        • et al.
        Accelerating the development of innovative cellular therapy products for the treatment of cancer.
        Cytotherapy. 2020; 22: 239-246https://doi.org/10.1016/j.jcyt.2020.01.014
        • Arcidiacono JA
        • Bauer SR
        • Kaplan DS
        • Allocca CM
        • Sarkar S
        • Lin-Gibson S.
        FDA and NIST collaboration on standards development activities supporting innovation and translation of regenerative medicine products.
        Cytotherapy. 2018; 20: 779-784https://doi.org/10.1016/j.jcyt.2018.03.039
        • Yeago C
        • Roy K.
        Cell manufacturing innovation facility: use of GMP-compliant space to accelerate advances in therapeutic cell production.
        Cytotherapy. 2020; 22: S163https://doi.org/10.1016/j.jcyt.2020.03.341
        • Lysaght T
        • Munsie M
        • Castricum A
        • Hui JHP
        • Okada K
        • Sato Y
        • et al.
        A roundtable on responsible innovation with autologous stem cells in Australia, Japan and Singapore.
        Cytotherapy. 2018; 20: 1103-1109https://doi.org/10.1016/j.jcyt.2018.06.004
        • Styhre A
        • Norbäck M.
        The passion and the interests in life science venturing.
        Eur J Inn Mnagmnt. 2018; 22: 175-192https://doi.org/10.1108/EJIM-08-2017-0098
        • Janeway WH
        • Nanda R
        • Rhodes-Kropf M.
        Venture capital booms and start-up financing.
        Annu Rev Fin Econ. 2021; 13: 111-127https://doi.org/10.1146/annurev-financial-010621-115801
        • Litau E.
        Entrepreneurship and Economic Growth: A look from the perspective of cognitive economics.
        in: Proceedings of the 2018 9th International Conference on E-business, Management and Economics - ICEME 2018. ACM Press, New York2018: 143-147https://doi.org/10.1145/3271972.3271978
        • Obschonka M
        • Moeller J
        • Goethner M.
        Entrepreneurial passion and personality: the case of academic entrepreneurship.
        Front Psychol. 2018; 9: 2697https://doi.org/10.3389/fpsyg.2018.02697
      1. Employee innovativeness in organizations: a review of the antecedents - LSE Research Online n.d. http://eprints.lse.ac.uk/49813/ [accessed 9.11.2021].

        • Hendarman AF
        • Cantner U.
        Soft skills, hard skills, and individual innovativeness.
        Eurasian Bus Rev. 2018; 8: 139-169https://doi.org/10.1007/s40821-017-0076-6
      2. The Value of Soft Skills in the Labor Market | NBER n.d. https://www.nber.org/reporter/2017number4/value-soft-skills-labor-market [accessed 9.11.2021].

        • Börner K
        • Scrivner O
        • Gallant M
        • Ma S
        • Liu X
        • Chewning K
        • et al.
        Skill discrepancies between research, education, and jobs reveal the critical need to supply soft skills for the data economy.
        Proc Natl Acad Sci USA. 2018; 115: 12630-12637https://doi.org/10.1073/pnas.1804247115
        • Vogler JS
        • Thompson P
        • Davis DW
        • Mayfield BE
        • Finley PM
        • Yasseri D.
        The hard work of soft skills: augmenting the project-based learning experience with interdisciplinary teamwork.
        Instr Sci. 2017; 46: 1-32https://doi.org/10.1007/s11251-017-9438-9
        • Secundo G
        • Del Vecchio P
        • Simeone L
        • Schiuma G
        Creativity and stakeholders’ engagement in open innovation: Design for knowledge translation in technology-intensive enterprises.
        J Bus Res. 2019; https://doi.org/10.1016/j.jbusres.2019.02.072
        • Succi C
        • Canovi M.
        Soft skills to enhance graduate employability: comparing students and employers’ perceptions.
        Studies in Higher Education. 2019; : 1-14https://doi.org/10.1080/03075079.2019.1585420
        • Kipper LM
        • Iepsen S
        • Dal Forno AJ
        • Frozza R
        • Furstenau L
        • Agnes J
        • et al.
        Scientific mapping to identify competencies required by industry 4.0.
        Technol Soc. 2021; 64101454https://doi.org/10.1016/j.techsoc.2020.101454
        • Leydesdorff L
        • Ivanova I.
        The measurement of “interdisciplinarity” and “synergy” in scientific andextra-scientific collaborations.
        J Assoc Inf Sci Technol. 2020; https://doi.org/10.1002/asi.24416
      3. Formal or Informal Mentoring: What Drives Employees to Seek Informal Mentors? on JSTOR n.d. https://www.jstor.org/stable/44114733/ [accessed 11.11.2021].

        • Mullen CA
        • Klimaitis CC.
        Defining mentoring: a literature review of issues, types, and applications.
        Ann N Y Acad Sci. 2021; 1483: 19-35https://doi.org/10.1111/nyas.14176
        • Moon TM
        Mentoring the next generation for innovation in today’s organization.
        J Strateg. Leadership. 2014; 5 (ISSN 1941-4668): 23-35
        • Ciuchta MP
        • Letwin C
        • Stevenson R
        • McMahon S
        • Huvaj MN.
        Betting on the coachable entrepreneur: signaling and social exchange in entrepreneurial pitches.
        Ent Theory & Pract. 2017; 42104225871772552https://doi.org/10.1177/1042258717725520
        • Lundqvist MA
        • Williams Middleton KL
        Academic entrepreneurship revisitedࣧuniversity scientists and venture creation.
        J Small Bus Ente Dev. 2013; 20: 603-617https://doi.org/10.1108/JSBED-04-2013-0059
        • Gocłowska MA
        • Ritter SM
        • Elliot AJ
        • Baas M.
        Novelty seeking is linked to openness and extraversion, and can lead to greater creative performance.
        J Pers. 2019; 87: 252-266https://doi.org/10.1111/jopy.12387
        • McCully JD
        • Levitsky S
        • Del Nido PJ
        • Cowan DB.
        Mitochondrial transplantation for therapeutic use.
        Clin Transl Med. 2016; 5: 16https://doi.org/10.1186/s40169-016-0095-4
        • Shiu E
        Interdisciplinarity and scientific creativity. creativity research: an inter-disciplinary and multi-disciplinary research handbook.
        (editor) Routledge, London2014: 49-68https://doi.org/10.4324/9780203104392-11
        • Hidalgo ES.
        Adapting the scrum framework for agile project management in science: case study of a distributed research initiative.
        Heliyon. 2019; 5: e01447https://doi.org/10.1016/j.heliyon.2019.e01447
        • Lane JP
        • Flagg JL.
        Translating three states of knowledge–discovery, invention, and innovation.
        Implement Sci. 2010; 5: 9https://doi.org/10.1186/1748-5908-5-9
        • Engel JS.
        Global clusters of innovation: lessons from Silicon valley.
        Calif Manage Rev. 2015; 57: 36-65https://doi.org/10.1525/cmr.2015.57.2.36
        • Etzkowitz H
        • Zhou C.
        The triple helix: university–industry–government innovation and entrepreneurship.
        Routledge, London2017https://doi.org/10.4324/9781315620183
        • Pradhan RP
        • Arvin MB
        • Nair M
        • Bennett SE.
        The dynamics among entrepreneurship, innovation, and economic growth in the Eurozone countries.
        Journal of Policy Modeling. 2020; 42: 1106-1122https://doi.org/10.1016/j.jpolmod.2020.01.004
        • Dias Sant´Ana T
        • de Souza Bermejo PH
        • Moreira MF
        • de Souza WVB.
        The structure of an innovation ecosystem: foundations for future research.
        Management Decision. 2020; 58: 2725-2742https://doi.org/10.1108/MD-03-2019-0383
        • Russell MG
        • Smorodinskaya NV.
        Leveraging complexity for ecosystemic innovation.
        Technol Forecast Soc Change. 2018; https://doi.org/10.1016/j.techfore.2017.11.024
        • Sisa I
        • Abad A
        • Espinosa I
        • Martinez-Cornejo I
        • Burbano-Santos P.
        A decade of Ecuador´s efforts to raise its health research output: a bibliometric analysis.
        Glob Health Action. 2021; 141855694https://doi.org/10.1080/16549716.2020.1855694
        • Abdul Razak A
        • Murray PA
        Innovation strategies for successful commercialisation in public universities.
        International Journal of Innovation Science. 2017; 9: 296-314https://doi.org/10.1108/IJIS-05-2017-0035
        • Kulkov I
        • Hellström M
        • Wikström K.
        Identifying the role of business accelerators in the developing business ecosystem: the life science sector.
        Eur J Innovation Management. 2021; 24: 1459-1479https://doi.org/10.1108/EJIM-04-2020-0139
      4. Biert. Assessing technology for a deep tech venture builder design of a framework for the assessment of technology for a deep tech venture building program. Student thesis: Master, 2020.

        • Huang-Saad A
        • Fay J
        • Sheridan L.
        Closing the divide: accelerating technology commercialization by catalyzing the university entrepreneurial ecosystem with I-CorpsTM.
        J Technol Transf. 2016; : 1-21https://doi.org/10.1007/s10961-016-9531-2
        • Borrás S.
        Innovation policies in Europe and the US.
        Routledge, London2018https://doi.org/10.4324/9781315195902
        • Perrin J-C.
        New technologies, local synergies and regional policies in europe. High technology industry and innovative environments: the European experience.
        Routledge, London2018: 139-162https://doi.org/10.4324/9781315149769-7
        • Pradhan RP
        • Arvin MB
        • Nair M
        • Bennett SE
        • Bahmani S.
        Short-term and long-term dynamics of venture capital and economic growth in a digital economy: a study of European countries.
        Technol Soc. 2018; 57: 125-134https://doi.org/10.1016/j.techsoc.2018.11.002
        • Devigne D
        • Manigart S
        • Vanacker T
        • Mulier K.
        Venture capital internationalization: synthesis and future research directions.
        J Econ Surv. 2018; 32: 1414-1445https://doi.org/10.1111/joes.12276
      5. ¿Cómo optimizar el proceso de selección de oportunidades de empresas “Startups” en un fondo capital de riesgo para la decisión de inversión? - hdl:10726/2235 n.d. https://repository.cesa.edu.co/handle/10726/2235/ [accessed 26.11.2021].

      6. Abstracts of the 24th annual congress of the SBRA, 2020 (virtual meeting).
        JBRA Assist Reprod. 2020; 24: 518-524https://doi.org/10.5935/1518-0557.20200072
        • Damodaran A.
        country risk: determinants, measures and implications - the 2021 edition.
        SSRN Journal. 2021; https://doi.org/10.2139/ssrn.3879109
        • Köhn A.
        The determinants of startup valuation in the venture capital context: a systematic review and avenues for future research.
        Manag Rev Q. 2017; 68: 1-34https://doi.org/10.1007/s11301-017-0131-5
        • Fracica Naranjo G.
        La financiación empresarial y la industria del capital de riesgo: estructura y conceptos.
        RevEscAdmNeg. 2009; : 31-66https://doi.org/10.21158/01208160.n66.2009.472
        • Miranda Miranda JF
        • Arroyave CE
        • Bolivar G.
        Las Empresas de Base Tecnológica e Innovadoras y su relación con los Fondos de Inversión en Capital.
        Primera Edición. Fundación Cultural Javeriana de Artes Gráficas, 2007
      7. Series A, B, C Funding: Averages, Investors, Valuations n.d. https://www.fundz.net/what-is-series-a-funding-series-b-funding-and-more#b [accessed 26.11.2021].

        • Nedayvoda A
        • Delavelle F
        • So HY
        • Graf L
        • Taupin L.
        Financing Deep Tech. 2021;