Abstract
The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell
(ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal
stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym
“MSCs” but recommends this be (i) supplemented by tissue-source origin of the cells,
which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous
evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate
MSC properties, which are not generically defined but informed by the intended therapeutic
mode of actions.
Key Words
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Article info
Publication history
Published online: September 13, 2019
Accepted:
August 19,
2019
Received:
June 24,
2019
Identification
Copyright
© 2019 International Society for Cell and Gene Therapy. Published by Elsevier Inc. All rights reserved.
