Comparative study of hypoxic and normoxic preconditioned mesenchymal stem cell derived extracellular vesicles and their therapeutic implications

      Extracellular vesicles (EVs) produced by mesenchymal stem cells (MSCs) have been considered to be a major paracrine effector in MSC therapeutic responses of which exosomes are thought to be the active component. Human MSCs cultured under low oxygen conditions (hypoxic) have been shown to produce EVs with a higher therapeutic potential than those produced from MSCs cultured under atmospheric oxygen conditions (normoxic). This study aims to understand and characterize the differences between MSC-EVs derived under normoxic and hypoxic conditions.
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