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Rapid and robust CD4+ and CD8+ T-, NK-, B- and monocyte cell reconstitution after nicotinamide-expanded cord blood (nicord) transplantation

      Nicotinamide-expanded cord blood (NiCord) is a promising alternative source for allogeneic hematopoietic cell transplantation (HCT) when an HLA-id donor is lacking. A phase 1/2 trial, with standalone NiCord HCT, showed rapid neutrophil engraftment (11days) and thrombocyte engraftment (34days). However, successful CD4+ immune reconstitution (IR) has shown to be crucial for favorable survival chances (Admiraal JACI2017). We therefore evaluated early IR after NiCord HCT.
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