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In vivo tracking of CAR-T by [18f]BF4- PET/CT in human breast cancer xenografts reveals differences in CAR-T tumour retention

  • Author Footnotes
    * Corresponding author.
    E. Kurtys
    Footnotes
    * Corresponding author.
    Affiliations
    Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
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  • L. Lim
    Affiliations
    Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
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  • F. Man
    Affiliations
    Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
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  • A. Volpe
    Affiliations
    Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
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  • G. Fruhwirth
    Affiliations
    Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

    Comprehensive Cancer Imaging Centre, King's College London & UCL, London, United Kingdom
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  • Author Footnotes
    * Corresponding author.
      Introduction: Genetically modified T cells are emerging anti-cancer immunotherapeutics. Challenges for T cell immunotherapy of solid tumours include on-target off-site toxicities against healthy tissues, in vivo relocalization reducing on-site efficacy, and cytokine storm. Non-invasive cell tracking can characterise in vivo cell therapy distribution and relocalization kinetics as well as identify off-site targets.
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