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Large-scale, single cell RNA sequencing defines novel cellular subsets required for cardiac repair

  • N. Farbehi
    Affiliations
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia

    Stem Cells Australia, Australian Research Council, Melbourne, Victoria, Australia

    Development and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia
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  • R. Patrick
    Affiliations
    Stem Cells Australia, Australian Research Council, Melbourne, Victoria, Australia

    Development and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia
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  • M. Xaymardan
    Affiliations
    Stem Cells Australia, Australian Research Council, Melbourne, Victoria, Australia

    Faculty of Dentistry, University of Sydney, Sydney, New South Wales, Australia
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  • R. Harvey
    Affiliations
    Stem Cells Australia, Australian Research Council, Melbourne, Victoria, Australia

    Development and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia
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  • Author Footnotes
    * Corresponding author.
    R. Nordon
    Footnotes
    * Corresponding author.
    Affiliations
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia

    Stem Cells Australia, Australian Research Council, Melbourne, Victoria, Australia
    Search for articles by this author
  • Author Footnotes
    * Corresponding author.
      A cell-based therapy for heart failure aims to reduce congestive cardiac failure or progression of ischaemic cardiomyopathy following myocardial infarction (MI). To date several thousand patients have been enrolled in clinical trials evaluating efficacy of various autologous cell sources. The mechanism of cell potency is very poorly understood and in most studies transplanted cells do not persist in cardiac tissues. We have applied large-scale, single cell RNA sequencing (scRNAseq) to shed light on the mechanism of endogenous cellular repair following myocardial infarction.
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