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Warming events and MSC cryopreservation: Observations that could lead to the development of surrogate tests for immunosuppressive activity

  • D. Chabot
    Affiliations
    Medical Affairs and Innovation, Héma-Québec, Québec, Quebec, Canada

    Biochemistry, Microbiology and Bioinformatics, Laval University, Québec, Quebec, Canada
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  • A. Lewin
    Affiliations
    Medical Affairs and Innovation, Héma-Québec, Québec, Quebec, Canada

    Faculty of Medicine and Health Science, University of Sherbrooke, Sherbrooke, Quebec, Canada
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  • L. Loubaki
    Affiliations
    Medical Affairs and Innovation, Héma-Québec, Québec, Quebec, Canada

    Biochemistry, Microbiology and Bioinformatics, Laval University, Québec, Quebec, Canada
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  • R. Bazin
    Affiliations
    Medical Affairs and Innovation, Héma-Québec, Québec, Quebec, Canada

    Biochemistry, Microbiology and Bioinformatics, Laval University, Québec, Quebec, Canada
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      Background: We recently showed that MSC can be cryopreserved without compromising their immunosuppressive functions but that warming events occurring on frozen MSC induce damages that impair their functional activity [
      • Chabot D.
      • Tremblay T.
      • Paré I.
      • Bazin R.
      • Loubaki L.
      ]. We further showed that MSC subjected to warming events retained a very good post-thaw viability whereas their ability to bind to plastic was decreased. In the present work, we analysed the correlation between loss of functional and adhesion properties induced by warming events on frozen MSC.
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      Reference

        • Chabot D.
        • Tremblay T.
        • Paré I.
        • Bazin R.
        • Loubaki L.
        Cytotherapy. 2017; 19: 978