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Eicosapentaenoic acid enhances mesenchymal stromal cell effects in experimental allergic asthma

      Rationale: Asthma is an increasing global health issue with no effective therapeutic interventions to repair the chronic airway remodeling that occurs. Systemic administration of mesenchymal stromal cells (MSCs) mitigates lung inflammation in experimental allergic asthma; however, effects on reducing airway remodeling are limited. Metabolites derived from eicosapentaenoic acid (EPA) supplementation may stimulate MSCs and potentiate their anti-inflammatory and anti-fibrogenic properties. The aim of this study was To investigate whether pre-treatment with EPA potentiates MSC therapeutic properties in experimental allergic asthma.
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