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Potential anti-inflammatory mechanism of action of mesenchymal stromal cells in osteoarthritis patients results in overall improvement in pain and symptoms

  • A. Chaboureau
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Cell Therapy Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • S. Bhatt
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Cell Therapy Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • A. Gomez-Aristizabal
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Cell Therapy Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • J. Chisholm
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Cell Therapy Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • A. Weston
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • A. Fazio
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • M. Kapoor
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • A. Keating
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Cell Therapy Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada

    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
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  • D. Ogilvie-Harris
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • N. Mahomed
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • R. Gandhi
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • W. Marshall
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • K. Syed
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada
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  • A. Naraghi
    Affiliations
    Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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  • J. Chahal
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada
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  • Author Footnotes
    * Corresponding author.
    S. Viswanathan
    Footnotes
    * Corresponding author.
    Affiliations
    Arthritis Program, University Health Network, Toronto, Ontario, Canada

    Cell Therapy Program, University Health Network, Toronto, Ontario, Canada

    Krembil Research Institute, University Health Network, Toronto, Ontario, Canada

    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Search for articles by this author
  • Author Footnotes
    * Corresponding author.
      We initiated the first Canadian clinical trial using autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) to treat 12 patients with Kellgren-Lawrence III or IV osteoarthritis (OA) of the knee. Patients received 1, 10 or 50 million MSCs in a single intra-articular injection in the affected knee.
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