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A phase I trial of mesenchymal stem cells transfected with a plasmid secreting interferon beta in advanced ovarian cancer

      Background: Treatment of ovarian cancer with a platinum-taxane is effective but associated with significant relapse. We demonstrated genetically modified mesenchymal stem cells (MSC) preferentially engraft and secrete gene products such as interferon beta (IFNB) at tumor sites, resulting in complete responses in animal models.
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