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Separation of lymphocytes using acoustic microfluidics

      Background: The development and manufacturing of cell therapies requires cost effective and scalable techniques for the manipulation of target cells. The first step in the production of these promising engineered cell therapies is separation of specific cellular fractions from clinical blood products. For lymphocyte-derived products, current techniques for cell purification include leukapheresis, density gradient separation, and magnetic sorting. We are currently developing a continuous flow process that uses disposable microfluidic cartridges that can be scaled for production or used in research labs to isolate enriched cell fractions from different blood products. Compared to the traditional methods described above, acoustic microfluidic separation is scalable to both high- and low-volume sample separation and has the ability to separate cells based on size, density, and compressibility.
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