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WT1 and PRAME mRNA transfected TLR 7/8-polarized fast DC lead to specific immune responses in AML patients and have an impact on progression free survival

      Age or co-morbidity factors reduce therapy options in patients diagnosed with acute myeloid leukemia (AML). We treated 5 AML patients in morphological remission after incomplete induction/consolidation chemotherapy with dendritic cells (DCs) targeting WT-1 and PRAME. DCs were produced using a maturation cocktail containing the TLR 7/8 ligand R848. DCs showed a polarized release of IL-12p70 combined with low IL-10.
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