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The role in immune-tolerance and possibility as a target for immunotherapy of MDSC-like myeloid blasts in AML

      Background: Myeloid-derived suppressor cells (MDSCs) is a heterogenous cell population having an ability to suppress T-cell function. Due to their suppressive effects on immunity, MDSCs has been known to be associated with poor prognosis in various solid cancers. However, the role of MDSC in myeloid neoplasm are unclear. So, we elucidated the role of leukemic subpopulation showing CD11b+CD33+HLA-DR immunophenotype, which resembles MDSCs.
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