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Administration of T cells targeting tumor associated antigens to patients with myeloma

      Allogeneic hematopoietic stem cell transplant (HSCT) remains the only curative immunotherapy for patients (pts) with multiple myeloma (MM). However, high rates of transplant-related mortality (~30%) limits the applicability of this approach. Thus, to separate the beneficial postHSCT “graft versus myeloma” effect from the antecedent toxicities, we developed a strategy to enrich autologous MM-specific T cells ex vivo by stimulating PBMCs with overlapping peptide libraries of 5 MM expressed tumor associated antigens (TAA), PRAME, SSX2, MAGEA4, NY-ESO1 and Survivin.
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