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Differing co-stimulatory, linker and spacer domains produce variations in CD4 and CD8 cell composition and cytotoxic potential in CD19-specific chimeric antigen receptor (CAR19) T cells generated with the piggyBac transposase

  • D. Bishop
    Affiliations
    Westmead Institute for Medical Research, Sydney, New South Wales, Australia

    Haematology Department, Westmead Hospital, Sydney, New South Wales, Australia

    Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
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  • N. Xu
    Affiliations
    Cord & Marrow Transplant Facility, Sydney Children's Hospital, Sydney, New South Wales, Australia

    Children's Cancer Institute, University of New South Wales, Sydney, New South Wales, Australia
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  • S. Shen
    Affiliations
    Cord & Marrow Transplant Facility, Sydney Children's Hospital, Sydney, New South Wales, Australia

    Children's Cancer Institute, University of New South Wales, Sydney, New South Wales, Australia
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  • T. O'Brien
    Affiliations
    Cord & Marrow Transplant Facility, Sydney Children's Hospital, Sydney, New South Wales, Australia

    Children's Cancer Institute, University of New South Wales, Sydney, New South Wales, Australia
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  • D. Gottlieb
    Affiliations
    Westmead Institute for Medical Research, Sydney, New South Wales, Australia

    Haematology Department, Westmead Hospital, Sydney, New South Wales, Australia

    Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
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  • A. Dolnikov
    Affiliations
    Cord & Marrow Transplant Facility, Sydney Children's Hospital, Sydney, New South Wales, Australia

    Children's Cancer Institute, University of New South Wales, Sydney, New South Wales, Australia
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  • K. Micklethwaite
    Affiliations
    Westmead Institute for Medical Research, Sydney, New South Wales, Australia

    Haematology Department, Westmead Hospital, Sydney, New South Wales, Australia

    Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
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      Aim: CAR19 T cells have efficacy against B cell malignancies, however data regarding the relationship of CAR structure, product CD4/CD8 composition and killing activity is limited. We examined these parameters whilst optimising low-cost piggyBac transposase-generated CAR19 T cells for clinical use.
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