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Low IL-2 concentration favors generation of early memory T cells over terminal effectors during CAR T-cell expansion

      Adoptive T-cell therapy offers new options for cancer treatment. The therapeutic efficacy of T-cell therapy is linked to the persistence of administrated T cells, which is dependent on T-cell memory. Hence, the need for cells possessing early memory phenotypes in T-cell products is evident. The amount of interleukin-2 (IL-2) supplementation during in vitro expansion affects T-cell proliferation and effector differentiation. Here, we present a simplified and cost-effective expansion method for the production of chimeric antigen receptor (CAR) T cells with potentially improved therapeutic capacity.
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