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Balance of anti-CD123 Chimeric Antigen Receptor (CAR) binding affinity and density for the targeting of Acute Myeloid Leukemia

      Chimeric Antigen Receptors (CARs)-redirected T lymphocytes are a promising immunotherapeutic approach, nowadays object of accurate preclinical evaluation also for Acute Myeloid Leukemia (AML) targeting. We recently developed a CAR against the CD123 antigen, found to be over-expressed on AML blasts and leukemic stem cells (LSCs). However, the potential recognition of low CD123-positive healthy tissues, through the so called “on-target-off-organ” effect, limits the safe clinical employment of CAR-T cells.
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