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Successful engraftment but high viral reactivation after reduced intensity unrelated umbilical cord blood transplantation for sickle cell disease

      Introduction: HLA-matched sibling donor (MSD) hematopoietic stem cell transplant is curative in >92% of patients with sickle cell disease (SCD) but only 18% have MSD. Unrelated cord blood transplantation (UCBT) expands donor options but is associated with high graft rejection rates (50–62%). We hypothesized that a previously used reduced intensity conditioning (RIC) regimen when combined with thiotepa would have acceptable toxicity and support donor engraftment after UCBT for SCD.
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