Graft-versus-host disease (GvHD) is a severe complication in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). Mesenchymal stromal cells (MSCs) have been extensively used as second-line treatment for acute GvHD. Cord blood (CB) MSCs display low immunogenicity which makes them suitable for an allogeneic use. Herein we reported the infusion of CB-MSCs to treat three patients with severe resistant aGvHD and two patients with overlap syndrome after HSCT.
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