Rationale: Chronic obstructive pulmonary disease (COPD) is a devastating disease affecting millions
worldwide, and therapeutic options are limited. One-way endobronchial valves (EBV)
have been used in emphysema patients with dynamic hyperinflation, heterogeneity, and
collateral ventilation to reduce lobar volume and improve lung function. However,
EBV may increase rates of respiratory infection, COPD exacerbation, and hemoptysis.
Mesenchymal stromal cells (MSCs) secrete antibacterial peptides, promote the anti-inflammatory
M2 phenotype, and increase phagocytic activity. Thus, we hypothesized that administration
of MSCs prior to EBV placement would improve lung function and quality of life in
patients with severe heterogeneous COPD.
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