Rationale: Chronic obstructive pulmonary disease (COPD) is a devastating disease affecting millions worldwide, and therapeutic options are limited. One-way endobronchial valves (EBV) have been used in emphysema patients with dynamic hyperinflation, heterogeneity, and collateral ventilation to reduce lobar volume and improve lung function. However, EBV may increase rates of respiratory infection, COPD exacerbation, and hemoptysis. Mesenchymal stromal cells (MSCs) secrete antibacterial peptides, promote the anti-inflammatory M2 phenotype, and increase phagocytic activity. Thus, we hypothesized that administration of MSCs prior to EBV placement would improve lung function and quality of life in patients with severe heterogeneous COPD.
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