Introduction: In experimental models, the administration of mesenchymal stromal cells (MSC) reduces
myocardial and renal damage, mainly through paracrine mechanisms. Thus, for translational
purposes, it is essential to establish whether donor age influences the paracrine
properties of human MSC. Accordingly, we aimed to compare the effects of conditioned
medium (CM) derived from very young fetal MSC (F-CM) and with CM derived from adult
bone marrow MSC (o-CM; age >65 years) in well-established experimental models of acute
myocardial (AMI) and renal damage (AKI).
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