Introduction: Bone marrow derived mesenchymal stem cells (MSC) represent an attractive cellular
therapeutic target given their immunosuppressive and tolerogenic properties and relative
immune privilege. Preclinical studies and human trials in graft versus host disease
suggest potential efficacy in bronchiolitis obliterans syndrome (BOS). The purpose
of this dual centre, phase 1 study (www.clinicaltrials.gov NCT01175655) was to explore the feasibility and safety of delivery of allogeneic
MSC in patients with BOS complicating lung transplantation.
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