Abstract| Volume 18, ISSUE 6, SUPPLEMENT , S15, June 2016

Phase II Clinical Trial of Allodepleted T Cell Immunotherapy (ATIR101) Post-Transplant Results in Decreased Transplant-Related Mortality and Improved Survival in Acute Leukemia Patients Undergoing T-Depleted Haploidentical Stem Cell Transplantation

      Introduction: Haploidentical donors may resolve the shortage of available HLA-matched donors for the treatment of blood cancers requiring hematopoietic stem cell transplantation (HSCT). However, to prevent graft-versus-host disease (GVHD), haploidentical HSCT requires alloreactive T-cell depletion. We developed a strategy that allows donor lymphocyte infusion post-HSCT without inducing severe GVHD and maintaining reactivity against viruses and leukemic cells.
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