Introduction: Haploidentical donors may resolve the shortage of available HLA-matched donors for the treatment of blood cancers requiring hematopoietic stem cell transplantation (HSCT). However, to prevent graft-versus-host disease (GVHD), haploidentical HSCT requires alloreactive T-cell depletion. We developed a strategy that allows donor lymphocyte infusion post-HSCT without inducing severe GVHD and maintaining reactivity against viruses and leukemic cells.
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