As cellular therapeutics move from small scale to large scale manufacturing, systems
to allow for scalability while keeping safety and regulatory concerns managed become
critical. Three dimensional culture in bioreactors with microcarriers has been evaluated
as a means to reach this end. In this study, a novel bioreactor system (MAG 3L, PBS
Biotech) was employed in conjunction with non-coated plastic microcarriers (Star Plus,
Pall Medical) and xenogenic free medium containing human platelet lysate (Stemulate
NH, Cook Regentec).
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