Background: Obesity and metabolic disorders prevalence increased dramatically over the last decades
and they have become pandemic. The potential use of brown adipose tissue (BAT) to
increase energy expenditure has gain tremendous interest over the past couple of years
since the discovery of functional BAT in healthy adults. Transplantation of brown
fat in small animal model systems has demonstrated that brown fat expansion could
possibly provide a novel therapeutic to combat obesity and related disorders. Because
of the lack of transplantable BAT for human application, tissue engineering of metabolically
active transplantable brown fat has recently emerged. We have previously describe
the isolation and characterization of human brown adipose-derived stem cells and successfully
demonstrated that they could be metabolically beneficial when transplanted in an animal
model of obesity using a biological scaffold. Here we investigate in vitro the potential
use of an immune-protecting encapsulation medical device in order to safely translate
this technology to human and avoid immune rejection of the transplant.
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