Abstract| Volume 16, ISSUE 4, SUPPLEMENT , S91, April 2014

QNPQ: a computer aided multi-target structural radioprotective peptide critical for the co-induction of the Slit2, Spondin1 protein ligand-induced function and homology modeling of the Robo-1 receptor reverse transcription sites: a combinatorial directed conservation motif based analysis

      An increasing amount of evidence from experimental and computational bioinformatic analysis suggests that there are many domains in DNA sequences that remain evolutionarily conserved. In some cases, these conserved patterns in a collection of unaligned DNA and protein sequences present the same functional and regulatory properties and are significant for the molecular role of these sequences. Discriminative motif finding algorithms aim to increase the sensitivity and selectivity of conserved motif discovery by utilizing a specific set of DNA and protein sequences, and searching for binding sites and homolog repeats among the sets of the selected sequences. In the present study we introduce a combined bioinformatic software-based discriminative methodology to detect short, highly and most conserved motifs between the DNA sequences within the proteins Slit-2 and Spondin-1 and their receptor Robo-1 and then, on finding out more motif conserved features about them including their physical regulatory properties, as well as their function as therapeutic adjuvants for the enhancement of host tolerance to aggressive chemoradiotherapy for eradicating metastatic cancers.
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