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Repeated intra articular injection of bone marrow derived mesenchymal stem cell in knee osteoarthritis: double blind randomized clinical trial

  • N. Aghdami
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • M. Ghorbani Liastani
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • M. Emadedin
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • F. Mohseni
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • R. Fazeli
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • R. Moghadasali
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • S. Mardpour
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • E. Hosseini
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • M. Niknejadi
    Affiliations
    2Reproductive Imaging at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • V. Azimian
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • N. Jaroughi
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • N. Labibzadeh
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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  • A. Mirazimi Bafghi
    Affiliations
    1Regenerative Biomedicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Tehran, Iran, Islamic Republic of
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      Recent non-randomized studies including our three previous phase I/II clinical trials have shown the safety of mesenchymal stem cells injection in the treatment of osteoarthritis. To investigate the effects of intra articular injection of autologous bone marrow derived mesenchymal stem cells (BM-MSC) on the symptoms of moderate to sever knee osteoarthritis we performed a double blind, placebo-controlled study in 46 patients.
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