Exosomes secreted by human cardiac progenitors contain micro-RNA with cardioprotective and pro-angiogenic activities

      Secreted factors account, in part, for beneficial effects of transplanted cells into infarcted hearts. Injected cells activate endogenous regenerative processes through paracrine mechanisms including microRNAs (miRNAs). Exosomes (Exo) act as intercellular carriers of proteins and miRNAs. We analyzed the miRNA transcriptional profile of Exo from human cardiac progenitor cells (Exo-CPC) in comparison with Exo from normal human dermal fibroblasts (Exo-F). We studied the effect of hypoxia on miRNAs in Exo-CPC, as well as the cardioprotective effects of selected miRNAs.
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