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Establishment and characterization of replicate senescence study models of human mesenchymal stem cells

      Mesenchymal stem cells (MSCs) are being actively developed for regenerative medicine and are sourced from a number of tissues including adipose (AD), bone marrow (BM) and Wharton’s jelly. However, MSCs enter into senescence in long-term in vitro culture. The regeneration potentials of MSCs also diminish with advanced age, thus, hampering the potentials of clinical applications of MSCs for tissue repair.
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