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Pamam dendrimer roles in gene delivery methods and stem cell research

      The pluripotent stem (iPS) cells were successfully produced from mouse embryonic fibroblast cells and after that the study of iPS cell has developed quickly. In the last years, the new and interesting field of stem cell nanotechnology has appeared. The main role of nanostructures and nanotechnology to the fundamental improvements in stem cell-based therapies for gene delivery and degenerative medicine has been identified. It is recognized that nanomaterials have several exceptional effects. Eventually, these effects can result in more technological possibilities along with more challenges. The use of nanotechnology in stem cell study has exiting technological opportunities, which supply a new prospect to solve present challenges confronting stem cell study. Polyamidoamine (PAMAM) dendrimers have been most extensively explored for biomedical application. PAMAM dendrimers are nanospherical, hyperbranched and monodispersive molecules exhibiting exclusive properties which make them very interesting carriers for drug and gene delivery.
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