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Autologous peripheral blood T lymphocytes transduced with an anti lewisy chimeric receptor gene can be infused safely and persist in patients with lewisy positive acute myeloid leukaemia

      High-risk acute myeloid leukaemia (AML) has a dismal prognosis with available treatments. This phase 1 study evaluated safety and immunological effects of infusing peripheral blood T-lymphocytes transduced with an anti-LewisY (LeY) chimeric antigen (CAR) receptor gene in high-risk patients with LeY positive AML.
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