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Effective targeting of primary human acute myeloid leukemia using anti-CD123 chimeric antigen receptor engineered T cells

      Most patients with AML are incurable. We recently reported on immunotherapy with anti-CD19 chimeric antigen receptor transduced autologous T cells (CART-19) in patients with CLL. Successful CART cell therapy relies on a suitable cell-surface target; identifying an AML-specific surface antigen is challenging as many antigens are shared between normal myeloid progenitors and AML blasts. We found CD123 to be the most frequently and highly expressed target among 26 AML specimens. Furthermore, CD123 was more highly expressed on AML blasts than on normal marrow cells.
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