Progress towards the cGMP production of plurip-otent stem cell derived red blood cells

      Whilst red cell supply is sufficient, safe and effective in most developed economies, there are problems in many countries in maintaining adequacy of supply, managing the risk of transmission of infectious agents and immune incompatibility between donor and recipient. Human embryonic and induced pluripotent stem cells (hESCs & hiPSC) have unique properties in that they can be maintained indefinitely in culture in an undifferentiated state and yet retain the ability to form all the cells and tissues within the body. They therefore offer a potentially scalable source from which to generate red cells (RBCs) for use in clinical transfusion.
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