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A tissue engineering construct comprising human endometrial mesenchymal stromal cells and polyamide/gelatin mesh evaluated in a preclinical animal model of pelvic organ prolapse repair

      Pelvic organ prolapse (POP) is the herniation of bladder, bowel and/or uterus into the vagina causing urinary incontinence and sexual dysfunction. POP results from childbirth injury. 11-19% of women will be treated for POP by reconstructive surgery with or without polypropylene mesh. Complication rates approach 30%. Our aim was to use a tissue engineering approach to determine whether human endometrial stromal cells (eMSC) purified from the regenerative uterine lining improves the performance of a composite polyamide/gelatin mesh in a rat model of wound repair.
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