News| Volume 12, ISSUE 3, P425-428, 2010

Developments in clinical cell therapy


      Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. The principles and practices of the diverse aspects of immune therapy for cancer, HSC transplantation and regenerative medicine have many commonalities. This meeting report summarizes a workshop sponsored by the National Heart, Lung and Blood Institute (NHLBI) and Production Assistance for Cellular Therapies (PACT), held on 23–24 April 2009 at the National Institutes of Health (NIH, USA). A series of scientific sessions and speakers highlighted key aspects of the latest scientific, clinical and technologic developments in cell therapy, involving a unique set of cell products with a special emphasis on converging concepts in these fields.

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Cytotherapy
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Suhoski M.M.
        • Golovina T.N.
        • Aqui N.A.
        • Tai V.C.
        • Varela-Rohena A.
        • Milone M.C.
        • et al.
        Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.
        Mol. Ther. 2007; 15: 981-988
        • Le Blanc K.
        • Frassoni F.
        • Ball L.
        • Locatelli F.
        • Roelofs H.
        • Lewis I.
        • et al.
        Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study.
        Developmental Committee of the European Group for Blood and Marrow Transplantation. Lancet. 2008; 371: 1579-1586
        • Le Blanc K.
        • Samuelsson H.
        • Gustafsson B.
        • Remberger M.
        • Sundberg B.
        • Arvidson J.
        • et al.
        Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells.
        Leukemia. 2007; 21: 1733-1738
        • Yee C.
        • Thompson J.A.
        • Byrd D.
        • Riddell S.R.
        • Roche P.
        • Celis E.
        • Greenberg P.D.
        Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with meta-static melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells.
        Proc Natl Acad Sci USA. 2002; 99: 16168-16173
        • Bollard C.M.
        • Gottschalk S.
        • Leen A.M.
        • Weiss H.
        • Straathof K.C.
        • Carrum G.
        • et al.
        Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer.
        Blood. 2007; 110: 2838-2845
        • DiGiusto D.L.
        • Cooper L.J.N.
        Preparing clinical-grade antigen-specific T cells for adoptive immunotherapy trials.
        Cytotherapy. 2007; 9: 613-629
        • Rosenberg S.A.
        • Restifo N.P.
        • Yang J.C.
        • Morgan R.A.
        • Dudley M.E.
        Adoptive cell transfer: a clinical path to effective cancer immunotherapy.
        Nat Rev Cancer. 2008; 8: 299-308
        • Levine B.L.
        • Humeau L.M.
        • Boyer J.
        • MacGregor R.R.
        • Rebello T.
        • Lu X.
        • et al.
        Gene transfer in humans using a conditionally replicating lentiviral vector.
        Proc Natl Acad Sci USA. 2006; 103: 17372-17377
        • Cooley S.
        • Gada P.
        • McKenna D.
        • McCullar V.
        • Fautsch S.
        • Verneris M.
        • et al.
        Successful haploidentical hematopoietic cell engraftment using a non-myeloablative preparative regimen including natural killer (NK) cells.
        50th ASH Annual Meeting Abstracts. Blood. 2008; 112: 307
        • Berg M.
        • Lundqvist A.
        • McCoy P.
        • Leigh S.
        • Fan Y.
        • Tawab A.
        • Childs R.
        Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells.
        Cytotherapy. 2009; 11: 341-355
        • Mailliard R.B.
        • Wankowicz-Kalinska A.
        • Cai Q.
        • Wesa A.
        • Hilkens C.M.
        • Kapsenberg M.L.
        • et al.
        Alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity.
        Cancer Res. 2004; 64: 5934-5937
        • Whiteside T.L.
        • Piazza P.
        • Reiter A.
        • Stanson J.
        • Connolly N.C.
        • Rinaldo R.R.
        • et al.
        Production of a dendritic cell-based vaccine containing inactivated autologous virus for therapy of patients with chronic human immunodeficiency virus type 1 infection.
        Clin. Vaccine Immunol. 2009; 16: 233-240
        • Love Z.
        • Wang F.
        • Dennis J.
        • Awadallah A.
        • Salem N.
        • Lin Y.
        • et al.
        Imaging of mesenchymal stem cell transplant by bioluminescence and PET.
        J Nucl Med. 2007; 48: 2011-2020
        • Ahrens E.T.
        • Flores R.
        • Xu H.
        • Morel P.A.
        In vivo imaging platform for tracking immunotherapeutic cells.
        Nat. Biotechnol. 2005; 23: 983-987
        • O’Gorman W.E.
        • Dooms H.
        • Thorne S.H.
        • Kuswanto W.F.
        • Simonds E.F.
        • Krutzik P.O.
        • et al.
        The initial phase of an immune response functions to activate regulatory T cells.
        J Immunol. 2009; 183: 332-339
        • Krutzik P.O.
        • Nolan G.P.
        Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
        Cytometry. 2003; 55: 61-70