Abstract
Background aims
Tissue-specific stem cells are a promising target for kidney regeneration, because
it has been shown that they play a primary role in kidney repair. Several methods
have been developed for the isolation of stem/progenitor cells from healthy kidneys
but the existence of these cells in chronically damaged kidneys has not been noticed
so far.
Methods
A mouse model of chronic kidney failure was developed by ligation of the left ureter
for 5 months, and then isolation of stem cells from this tissue as well as normal
kidneys was attempted.
Results
We found that multipotent stem cells could be isolated from both types of tissue.
In addition, the cells isolated from damaged kidneys showed potential for homing to
the site of injury and a renoprotective effect in an animal model of cisplatin-induced
nephropathy.
Conclusions
These results show that multipotent renoprotective stem cells exist in severely damaged
kidneys, which could be a target for designing new therapies.
Key Words
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Article info
Publication history
Accepted:
February 16,
2010
Received:
April 27,
2009
Identification
Copyright
© 2010 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.
